Molecular characterization of the Haemonchus contortus phosphoinositide-dependent protein kinase-1 gene (Hc-pdk-1)

FC Li; RB Gasser; JB Lok; PK Korhonen; L He; WD Di; FY Yin; R Zhou; YQ Zhou; JL Zhao; M Hu

Journal article

Molecular characterization of the Haemonchus contortus phosphoinositide-dependent protein kinase-1 gene (Hc-pdk-1)

FC Li, RB Gasser, JB Lok, PK Korhonen, L He, WD Di, FY Yin, R Zhou, YQ Zhou, JL Zhao, M Hu

Parasites and Vectors | BMC | Published : 2016

DOI: 10.1186/s13071-016-1351-6

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Abstract

Background: Phosphoinositide-dependent protein kinase-1 (PDK-1), which functions downstream of phosphoinositide 3-kinase (AGE-1) and activates protein kinases of the AGC family, plays critical roles in regulating biology processes, such as metabolism, growth, development and survival. In the free-living nematode Caenorhabditis elegans, PDK-1 is a key component of the insulin-like signalling pathway, regulating the entry into and exit from dauer (arrested development). Although it is proposed that similar molecular mechanisms control the transition from the free-living to the parasitic stages of nematodes, nothing is known about PDK-1 in Haemonchus contortus, a socioeconomically important gas..

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University of Melbourne Researchers

Robin B. Gasser Author

Pasi Korhonen Author

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Grants

Awarded by National Institutes of Health

Funding Acknowledgements

This study was supported by "National Natural Science Foundation of China (NSFC)" (Grant no. 31172310), the National Key Basic Research Program (973 program) of China (Grant No. 2015CB150300) and "Special Fund for Agro-scientific Research in the Public Interest, China" (Grant no. 201303037) to MH, by a grant from The National Institute of Health (NIH), USA (AI-50688) to JBL and by funds from the National Health and Medical Research Council (NHMRC) and the Australian Research Council (ARC) of Australia to RBG. This study was also supported by a Victoria Life Sciences Computation Initiative (VLSCI; grant number VR0007) on its Peak Computing Facility at the University of Melbourne, an initiative of the Victorian Government, Australia (RBG).